St Clare's was established in 1971 as a systemic, coeducational, regional high school catering for students from Taree, Forster/Tuncurry, Wingham, Bulahdelah, Krambach/Nabiac and Gloucester parishes. It continues a tradition of quality secondary education in the Manning/Great Lakes Region which commenced in 1926, at Taree, by the Sisters of St Joseph.
The Religious Education programme is a vital and integral component of the school serving as a means of its very existence. It seeks to provide knowledge of the Catholic faith; to deepen students' understanding of the gospel message and to cater for students' present needs and help prepare them for the future. It is enhanced by liturgical and associated activities (e.g ) camps, retreats and liturgies which bring the spiritual into students' lives in ways that are more meaningful to them.